Microsoft will be holding two separate conferences at this year's E3 gathering in June.
Aaron Greenberg's blog announced that the Natal's event will be held on Sunday and that Microsoft will hold a conference for the XBox 360 on Monday. This appears to show the importance Microsoft is placing on Natal while also showing that it is also meant for a different audience than the more traditional Xbox 360 demographic.
With the recent announcement of Nintendo's 3DS and all the fuss Sony has been making about Move, this E3 should be one of the more exciting in recent history.